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The Capital One Cup victory was a game of many firsts: it was the Dutch boss' first competitive win as Saints coach, while Jack Cork and Graziano Pellè got their first goals in the red and white stripes of Southampton.
Southampton's mid-week win saw Ronald Koeman field a strong team barring a few omissions, namely Morgan Schneiderlin and Ryan Bertrand.
Expect Koeman to play a similar team against West Ham in today's 3pm kick-off. Lloyd Isgrove hobbled off the pitch in the first half and is likely to be unavailable. Neither Schneiderlin nor Bertrand have any reported injuries ahead of today's game, with Koeman suggesting they were just being rested ahead of today's fixture - so they're expected to be in today's starting XI.
The Millwall game saw Gastón Ramírez see some game time as he battles back to fitness, so he is likely to be in the squad. It's also expected Florin Gardos will feature in the squad, though it's not clear if he is match-fit yet as he recovers from a muscle injury gained before joining the Saints.
One summer signing who will not be featuring today is Saphir Taïder, who has left the club for Italian outfit Sassuolo without even kicking a ball for Saints in a competitive game. Taïder reportedly struggled to adapt to English life and wasn't training to Koeman's high standards.
West Ham go into today's game after a week of mixed fortunes. The Hammers thoroughly outplayed Crystal Palace last Saturday to win 3-1 at Selhurst Park. The East London club then went on to be one of many big-team casualties in the League Cup, following their loss on penalties to League One club Sheffield United.
Sam Allardyce's men have been playing some attractive football this season, thanks to summer signings Mauro Zarate and Enner Valencia. These two are likely to feature, while new loan signing Alex Song will not have joined in time to face the Saints.
West Ham will also be without the likes of Andy Carroll, Matt Jarvis, Carl Jenkinson and James Collins who are all sidelined with injury.