Jos Hooiveld is set to complete a season-long loan move to Norwich City ahead of tonight's 11pm transfer deadline.
Hooiveld, 31, will be deemed surplus to requirements by manager Ronald Koeman following the expected arrival of Toby Alderweireld from Atlético Madrid.
The Dutchman joined Saints following an unsuccessful spell at Celtic, and became a firm fan favourite as he played a considerable role in the club's return to the Premier League, scoring seven goals in the process.
However, Hooiveld appeared to struggle with life in the Premier League and found himself lacking match action after the arrivals of Maya Yoshida in 2012 and Dejan Lovren in 2013.
This summer has seen Florin Gardos and Toby Alderweireld join José Fonte and Maya Yoshida in the defensive department, meaning Hooiveld is likely to be frozen out.
Norwich City are keen to secure Hooiveld on a loan deal before tonight's deadline.
The deal will mean that Hooiveld will see out the final year of his Southampton contract with the Championship side.
Meanwhile, Jake Sinclair has completed a season-long loan move to Scottish Championship side Hibernian.
A tumultuous summer window saw Saints lose Calum Chambers, Dejan Lovren, Luke Shaw, Adam Lallana and Rickie Lambert to a combination of Arsenal, Liverpool and Manchester United - but the money has been reinvested in nine new faces.
Hooiveld looks certain to be the final departure ahead of tonight's deadline, with no move for the discontented Artur Boruc appearing to be imminent.