Last time Saints played the Eagles away from home, they won 1-3 with Sadio Mane running the show. That Boxing Day win meant Southampton moved up to fourth in the Premier League's Champions League berths while Palace slipped down into the relegation zone.
Much has changed over the last year. Palace have since hired former Southampton manager Alan Pardew, who has done a good job in steadying the ship and has helped establish the club as a tough, attacking Premier League side.
Palace currently sit above Saints in the table and have already earned some big away wins at Chelsea and Liverpool so it's unlikely Southampton will have their way with their opponents as easily as last year.
Southampton's Victor Wanyama has overcome an ankle niggle so could feature. However, Jay Rodriguez, Florin Gardos and Fraser Forster all remain sidelined through injury.
Meanwhile, Crystal Palace will be without Mile Jedinak, Dwight Gayle and Bakary Sako. Former Arsenal striker Marouane Chamakh could return to the Palace fold.
Crystal Palace haven't beat Southampton in their last 12 Premier League outings, drawing four and losing eight times.
Southampton have won their last seven league encounters against Palace in either the Premier League or Championship.
Crystal Palace have lost four home matches already this season: only Aston Villa's five top that figure.
Southampton are winless in their last three Premier League games.
Saints have not beaten a team in the top half of the table this season, having drawn three and lost three.
Crystal Palace have scored a league-high 45% of their goals from set-pieces.
Southampton have drawn four away matches this season - a league record equaled by Tottenham and Everton.
Bet Victor: Crystal Palace: 17/10 - Draw: 9/4 - Southampton: 19/10
Bet 365: Crystal Palace: 8/5 - Draw: 23/10 - Southampton: 2/1
How to Watch:
Date/time: 12/12/2015, 15:00 UTC (UK) - 10:00 ET (USA)
Venue: Selhurst Park, London, UK
TV: None (UK), NBCSN (USA)
Streaming: None (UK), NBCSN (USA)
Radio: BBC Radio Solent (UK)