Ronald Koeman's Southampton have lost five out of their last six outings in all competitions and need to start picking up points sooner rather than later if they wish to stay clear of the ensuing relegation dogfight.
Meanwhile, Arsenal are the visitors this week for the Saints, with Arsene Wenger's Gunners buoyed by their fantastic 2-1 win over Manchester City on Monday.
On Christmas day in 2014, Southampton were up in fifth in the league - one place above Arsenal in sixth. However, this year sees Arsenal up in second with Saints trailing behind by 15 points.
Southampton goalkeeper Maarten Stekelenburg is back in contention after overcoming a toe injury, while long-term absentees Florin Gardos, Jay Rodriguez and Fraser Forster are still sidelined through injury.
Arsenal star Alexis Sanchez remains injured as he recovers from a hamstring strain, while they are still missing Mikel Arteta, Jack Wilshere Santi Cazorla, Francis Coquelin and Danny Welbeck through injury.
Arsenal have lost just one of their last 11 meetings between the two sides - their last match against each other at St. Mary's on New Year's Day when Southampton ran out comfortable 2-0 winners.
The last time Southampton played Arsenal on Boxing Day was in 1989. They won 1-0 with Rod Wallace netting the winner.
Southampton have went six Premier League games without tasting victory.
Southampton have went five league matches without keeping a clean sheet.
Arsenal currently have a 100% record in December.
Arsenal have only ever lost one Premier League game on Boxing Day, winning 12 and drawing five.
Arsene Wenger's side have the best league defence so far this season, only conceding 14 goals.
Bet Victor: Southampton: 2/1 - Draw: 12/5 - Arsenal: 6/4
Bet 365: Southampton: 21/10 - Draw: 12/5 - Arsenal: 29/20
How to Watch:
Date/time: 19/12/2015, 19:45 UTC (UK) - 14:45 ET (USA)
Venue: St. Mary's Stadium, Southampton, UK
TV: BT Sport (UK), NBCSN (USA)
Streaming: BT Sport Online (UK), NBCSN (USA)
Radio: BBC Radio Solent (UK), TalkSport (UK)