Saturday afternoon sees the Saints host the Villains on the South Coast as Ronald Koeman's Southampton seek to avenge their 6-1 home drubbing at the hands of Liverpool on Wednesday night.
Aston Villa played away at St. Mary's a few weeks ago as they lost 2-1 to Southampton in the Capital One Cup - and new coach Remi Garde will be hoping to earn his first win in his tenure at Villa.
Last time Southampton played Aston Villa at home in the Premier League saw them run out 6-1 victors - with flying Senagalese forward notching the league's fastest ever hattrick in the process.
Villa are currently sitting at the foot of the table and have the lowest points tally in the history of the Premier League at this stage of the season.
Southampton captain Jose Fonte is a doubt to feature, having suffered a badly cut knee which forced him from not playing in his team's midweek defeat. Fraser Forster, Jay Rodriguez and Florin Gardos are still on the sidelines with injury.
Aston Villa will be missing both of their first-choice central defenders with Ciaran Clark suspended and captain Micah Richards sitting out with a knee injury.
Aston Villa have only beaten the Saints once in the last six meetings, with former captain Fabian Delph crashing home the winner in 2013.
Southampton's 6-1 League Cup defeat to Liverpool is their worst home loss in 56 years.
All of Saints' five Premier League wins have come against opposition sitting in the bottom seven of the table.
Aston Villa have gone 13 league games without a win, equaling a club record.
Remi Garde's men have only picked up one point from their last 10 matches - an away draw at Manchester City.
Bet Victor: Southampton: 8/15 - Draw: 16/5 - Aston Villa: 13/2
Bet 365: Southampton: 8/15 - Draw: 10/3 - Aston Villa: 6/1
How to Watch:
Date/time: 21/11/2015, 15:00 UTC (UK) - 10:00 ET (USA)
Venue: St. Mary's Stadium, Southampton, UK
TV: None (UK), NBCSN (USA)
Streaming: None (UK), NBCSN (USA)
Radio: BBC Radio Solent (UK)