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With City having secured second place in the league this season with a Champions League spot in the bag, the Citizens have little to play for bar pride in their last match in front of their home fans.
City are without Samir Nasri and Fernando in their final game of the season. Meanwhile, Frank Lampard could potentially make his last Premier League appearance against the Saints on Sunday.
Southampton will be missing Morgan Schneiderlin and Dusan Tadic. The South Coast club will also play City without striker Jay Rodriguez who suffered a serious knee injury against the Manchester club in April 2014.
Saints have hit a stuttering patch of form for the season close, though they ended that run with the 6-1 decimation of Aston Villa last Saturday. City, meanwhile, have hit a rich vein of form having won five games on the bounce.