Southampton will begin the season away to Newcastle United on Sunday the 9th of August, just three days after the away leg of their Europa League qualifying game.
Everton then visit St. Mary's the following weekend for the first home game of the new season.
Saints' sextuplet of opening fixtures is then completed by away games against Watford and West Bromwich Albion, with Norwich City and Manchester United visiting St. Mary's.
Just one other fixture fills September, with Saints facing Swansea City on the 26th of September.
October sees away trips to Chelsea and Liverpool alongside home clashes with Leicester City and AFC Bournemouth - in the first of the two local fixtures for Saints next season.
Up next is November, which will see Saints travel to Sunderland and Manchester City, with a home game against Stoke City sandwiched in between.
The traditionally-busy festive period then sees Saints take on the burden of six games in 28 days, starting with Aston Villa's visit to St. Mary's.
Southampton then visit Selhurst Park to face Crystal Palace, before hosting the North London duo of Tottenham Hotspur and Arsenal on the 19th and 26th of December respectively.
The festive period is concluded for Saints with two away trips, firstly to the Boleyn Ground for the final time ahead of West Ham United's move to the Olympic Stadium, before Saints start 2016 with a trip to Carrow Road to face Norwich City on January the 2nd.
January continues with home games against Watford and West Bromwich Albion, before Ronald Koeman's men travel to face Louis van Gaal's Manchester United side at Old Trafford in the final fixture of January.
February takes a very London-centric feel, with an away game at Arsenal's Emirates Stadium to open the month. West Ham United then visit the south coast, before Saints head west to face Swansea City on the 13th of February. The month concludes with Chelsea travelling to St. Mary's on the 27th of February.
The second of the two local clashes with AFC Bournemouth kickstarts March, as Saints visit Dean Court on the first day of the month, a Tuesday evening. An away trip to Stoke City's Britannia Stadium home is then sandwiched between home games against Sunderland and Liverpool.
April starts with a visit to the King Power Stadium to face Leicester City, before Newcastle United visit St. Mary's on the 9th of April.
Consecutive away games at Goodison Park and Villa Park then follow, as Saints face Everton and Aston Villa respectively, before finishing the month with the hosting of Manchester City.
There are just two fixtures in May, as the Premier League season comes to a close. The final away game of the season is a trip to White Hart Lane to face Tottenham Hotspur on the 7th of May, before the season ends with a home game against Crystal Palace on the 15th.
A full fixture list is available below, courtesy of Southampton Football Club.
* Please be aware that all dates are subject to change, due to Southampton's commitments in the Europa League.