Ronald Koeman and his Southampton side will be hoping they can make it two wins in a row away at Manchester United as the Saints visit the Red Devils at Old Trafford.
Last season saw Southampton's impressive defence in full swing as United were limited to no shots on target all game. Saints' Serbian winger Dusan Tadic netted the winner following up from Graziano Pelle's shot that cannoned off the near post.
This 1-0 win was Southampton's first league win away at United for the first time in 27 years.
New Saints signing Charlie Austin could well make his debut for his club - helped by the news that Pelle is still struggling for fitness following a knee injury. But, Jay Rodriguez and Dlorin Gardos remain injured.
United boss Louis van Gaal will be without Ashley Young due to a groin tear, while Bastian Schweinsteiger, Michael Carrick, Phil Jones and Marcos Rojo all remain injured.
Saints have lost 23 Premier League matches against United - more than against any other opponent.
United have come from behind to beat Southampton on eight occasions - the most by one club against a single opponent.
All five league meetings between managers Ronald Koeman and Louis van Gaal have ended as away wins: three in the Premier League and previously in 2006-07 in the Dutch top flight when Van Gaal was at AZ Alkmaar and Koeman at PSV Eindhoven.
Bet Victor: Manchester United: 37/40 - Draw: 12/5 - Southampton: 15/4
Bet 365: Manchester United: 10/11 - Draw: 12/5 - Southampton: 15/4
How to Watch:
Date/time: Old Trafford, Manchester, UK
TV: None (highlights on Match of the Day, BBC1) (UK), NBCSN(USA)
Streaming: None (UK), NBCSN (USA)
Radio: BBC Radio Solent (UK)