Ronald Koeman's Saints played against Alan Pardew's Palace less than a month ago, with Southampton losing to the soaring Eagles 1-0 at Selhurst Park.
After a poor run of results in the Premier League, Koeman will be hoping Southampton pick up a positive result against Palace today to kickstart the second half of their season.
Crystal Palace actually knocked Southampton of the FA Cup in the fourth round last season, winning 3-2 at St. Mary's.
Southampton will be missing Italian international striker Graziano Pelle through a knee injury and Kenyan midfielder Victory Wanyama following his idiotic red card picked up against Norwich City last week.
Saints, however, will be welcoming back Cedric Soares and Juanmi who have returned to fitness.
Palace, on the other hand, could welcome back French midfielder Yohan Cabaye and winger Bakary Sako to the fold.
UPDATED: Official team line-ups
Bet Victor: Southampton: 20/21 - Draw: 5/2 - Crystal Palace: 31/10
Bet 365: Southampton: 10/11 - Draw: 13/5 - Crystal Palace: 7/2
How to Watch:
Date/time: 09/01/2016, 15:00 UTC (UK) - 10:00 ET (USA)
Venue: St. Mary's Stadium, Southampton, UK
TV: None (highlights on Match of the Day, BBC1) (UK), None (highlights on FOX Sports) (USA)
Streaming: None (UK), None (USA)
Radio: BBC Radio Solent (UK)