Charlie Austin netted a second half brace either side of a Nathan Redmond goal.
Sam Vokes scored a consolation from the spot denying Southampton a seven-straight clean sheet.
The Saints have picked up points in four consecutive Premier League matches (3W, 1D) whilst Burnley has just one win from their last five (1W, 3L, 1D).
Read the rest of our report here.
So, if you are based in the States, relive the game with the match highlights provided by NBC below!