Date/time: 03/11/2016, 20:05 (UK), 16:05 ET, 13:00=5 PT (USA)
Venue: St. Mary's Stadium, Southampton, UK
TV: BT Sport (UK), Fox Sports (USA) and check out LiveSoccerTV for alternatives.
Streaming: BT Sport (UK), Fox Sports GO (USA)
Radio: BBC Radio Solent (UK)
Southampton welcome Inter Milan in a key fixture for both teams' Europa League future.
Internazionale were the 1-0 victors in the return fixture two weeks ago, with Saints unlucky to not escape the San Siro with at least a point. However, much has happened since that time.
Inter boss Frank de Boer has since been sacked, while a positive point away at the Etihad was positive for Claude Puel's Southampton--though his side was taught a lesson in their 2-0 home loss to Chelsea on Sunday.
Southampton will be without striker Shane Long and full-back Cedric Soares who are still injured. Jeremy Pied, Matt Targett, Alex McCarthy, Jake Hesketh, and Harrison Reed are also out.
Southampton are second in Group K with four points from three games, two points behind leaders Sparta Prague. Inter meanwhile are bottom with three points.
Saints are unbeaten in Europe since 1981 and have lost just one of their last 15 home games in European competitions (W8 D6), losing 4-2 versus Sporting Lisbon in the Uefa Cup in October 1981.
Inter are without a win in their last five European away games (D3 L2). They have also lost four of their last five away European games in England; their win coming against Chelsea on the way to winning the Champions League in 2010.
Southampton have only faced six shots on target in the Europa League this season. Only St Etienne (5) and Shakhtar Donetsk (1) have faced fewer.
Bet 365: Southampton: 17/20 - Draw: 13/5 - Inter: 15/4
Bet Victor: Southampton: 20/23 - Draw: 13/5 - Inter: 17/5
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