Ronald Koeman was left disappointed after Saints' final fixture at Upton Park as his Southampton side were dominant throughout the first half, with only one goal to show for it, before a second half collapse saw the home team take the spoils.
Koeman will be hoping his side gets the better of Slaven Bilic's West Ham this time around.
New Saints striker Charlie Austin could be set to make his home debut this evening. Austin missed the Arsenal away game in midweek after picking up a slight knock in training.
Steven Davis is still out injured with a hamstring problem, while it's expected that Matt Targett is also set to miss today's game with an ankle injury - joining long-term crocks Jay Rodriguez and Florin Gardos on the sidelines.
Southampton's nemesis Andy Carroll is fit after a hamstring injury of his own. Angelo Ogbonna and new signing Sam Byram also look set to return to first team action having returned from illness and injury.
New West Ham signing Emmanuel Emineke could make his debut for the Hammers this afternoon. But, Diafra Sakho and Manuel Lanzini remain sidelined.
This game will be broadcast on NBC today in the USA. A huge audience awaits!
The last three games between the two sides at St. Mary's have ended in a draw - the last two were goalless.
West Ham have never won at St. Mary's.
Southampton have won their last three Premier League games - scoring nine goals and conceding zero in the process.
Fraser Forster has kept four clean sheets in the four games he's had since returning from injury.
West Ham have only lost one of their last 13 games in all competitions - winning five and drawing seven.
Bet Victor: Southampton: 4/5 - Draw: 13/5 - West Ham: 21/5
Bet 365: Southampton: 4/5 - Draw: 13/5 - West Ham: 17/4
How to Watch:
Date/time: 06/02/2016, 17:30 UTC (UK) - 12:30 ET (USA)
Venue: St. Mary's Stadium, Southampton, UK
TV: Sky Sports (UK), NBC (USA)
Streaming: None (UK), NBCSN (USA)
Radio: BBC Radio Solent (UK)