Ronald Koeman will have Sadio Mane available after last weekend's red card against Stoke City was overturned by the FA.
Speaking of suspensions, Southampton's mighty Kenyan Victor Wanyama will be returning to the Saints fold for the first time in five games following his bumper suspension from picking up a third red card this season.
Southampton captain Jose Fonte also returns having served this one game suspension following his red card against Sunderland.
Last time Southampton hosted Liverpool at St. Mary's, the scousers ran out 6-1 winners to progress in the League Cup. However, Saints did pick up a point at Anfield in the Premier League this season with a late equaliser courtesy of Mane - ruining Liverpool boss Jurgen Klopp's home debut in the league.
As well as the aforementioned League Cup win, Liverpool have also won their last two Premier League visits.
Christian Benteke needs one more goal to reach 50 in the league. The Belgian international has scored in each of his last two league games against Southampton.
Liverpool have scored 13 goals in their last four away league games.
Liverpool are unbeaten in their last eight games in all competitions.
Bet Victor: Southampton: 19/10 - Draw: 11/5 - Liverpool: 17/10
Bet 365: Southampton: 7/4 - Draw: 23/10 - Liverpool: 9/5
How to Watch:
Date/time: 20/03/2016, 13:30 (UK) - 09:30 ET (USA)
Venue: St. Mary's Stadium, Southampton, UK
TV: None (UK), None (USA)
Streaming: None (UK), NBCSN (USA)
Radio: BBC Radio Solent (UK)