This week sees Sam Allardyce and his Sunderland side return to St. Mary's. Last time around, under the tutelage of Gustavo Poyet, Sunderland were handed an 8-0 thrashing from Southampton. Allardyce's teams are typically hard to beat so there's little to no chance of such a repeat today.
Southampton boss Ronald Koeman will rue Tuesday's 2-0 loss away at Bournemouth further with two strikers in Charlie Austin and the in-form Shane Long being ruled out of contention through a hamstring injury and a minor knee injury respectively.
Meanwhile, Sunderland will be missing Lee Cattermole and Jeremain Lens as they are out with respective head and hernia injuries, though they could welcome back Irish stalwart John O'Shea back into the fold.
Sunderland have a lot on their plates right now with the combined drain of a relegation battle and the fallout of Adam Johnson's extra-curricular activities.
As mentioned above, Southampton recorded their record Premier League win over Sunderland last season with an 8-0 demolition.
Saints have lost two matches in a row - they haven't lost three in a row so far this season.
Sunderland have won just one of their last seven away matches in the league - drawing one and losing five.
Sunderland may have went on a five-game losing streak in December. But, they have only lost three of their subsequent nine fixtures.
Sunderland have gone 14 games without keeping a clean sheet.
Bet Victor: Southampton: 8/11 - Draw: 29/10 - Sunderland: 5/1
Bet 365: Southampton: 13/20 - Draw: 14/5 - Sunderland: 11/2
How to Watch:
Date/time: 06/02/2016, 15:00 (UK) - 10:00 ET (USA)
Venue: St. Mary's Stadium, Southampton, UK
TV: None (UK), None (USA)
Streaming: None (UK), NBCSN (USA)
Radio: BBC Radio Solent (UK)