Date/time: 19/08//2016, 20:00 (UK) - 15:00 ET, 12:00 PT (USA)
Venue: Old Trafford, Manchester, UK
TV: Sky Sports 1(UK), USA Network (USA), check out LiveSoccerTV for alternatives.
Streaming: SkyGo (UK), NBCSN (USA)
Radio: BBC Radio Solent (UK)
It's Southampton's first away game of the season and it couldn't have come against tougher opponents on paper. For Manchester United, it's safe to say they're in a better spot than they were under the tutelage of Louis van Gaal.
Buoyed by a commanding win over AFC Bournemouth last Sunday, United have strengthened a lot over the summer. Jose Mourinho is now the man at the helm and signings such as the mercurial Zlatan Ibrahimovic, Paul Pogba, Henrikh Mkhitaryan and Eric Bailly have improved the squad's spine and attacking options so sorely lacking last year.
Unfortunately for Southampton, it looks like all four of aforementioned signings are ready to play later tonight.
Saints are coming off a slightly disappointing 1-1 draw against Watford in the first game of the new Premier League campaign, though new signings Nathan Redmond and Pierre-Emil Hjobjerg look promising in particular.
Southampton captain Jose Fonte, who has been continually linked to joining up with compatriot Mourinho at United, is expected to be feature after missing out on last week's game following a long, and ultimately successful, Euro 2016 run with Portugal.
There is one notable omission for Saints tonight. England left-back Ryan Bertrand is still out through injury, so Matt Targett is expected to continue his role as his replacement in the Saints back four.
Southampton have won two games 1-0 away at Old Trafford for two seasons in a row now. Can Saints make it three in a row?
Prior to Saints' recent record at Old Trafford, Southampton hadn't won away to Manchester United for 27 years.
United are unbeaten at home since Saints won there in January thanks to a Charlie Austin header. United have won eight and drawn three in all competitions since that contest.
Under Louis van Gaal, United only conceded nine home goals all season in the 2015/16 campaign. The best ever record in England's top flight.
Meanwhile, Saints only conceded 19 goals away from home last season - the second lowest tally in the league only behind champions Leicester City.
But, Saints have not kept a clean sheet for 13 consecutive Premier League games.
Bet Victor: Manchester United: 1/2 - Draw: 17/5 - Southampton: 13/2
Bet 365: Manchester United: 1/2 - Draw: 7/2 - Southampton: 13/2
Discuss all of tonight's talking points in the comments below! COYR!