Date/time: 25/04/2017, 19:45 (UK), 14:45 ET, 11:45 PT (USA)
Venue: Stamford Bridge, London, UK
Streaming: Sky Go (UK), NBCSN (USA)
Radio: BBC Radio Solent (UK)
Little over a week since Saints were taught a lesson by Manchester City, Claude Puel's men square off against another one of the Premier League's major players tonight—Antonio Conte's Chelsea, who top the Premier League.
Southampton's midfield enforcer Oriel Romeu, a former Chelsea man, is available to face his old teammates tonight after completing his two-match ban.
Sam McQueen is a doubt for Saints, having incurred a minor groin strain.
Chelsea could welcome back captain Gary Cahill to the first team after he recovered from illness, while it's expected Conte will start both Diego Costa and Eden Hazard, who were warming the bench for the majority of Chelsea's win over Tottenham Hotspur in the FA Cup semi-final.
Stats Zone (via BBC Sport):
Chelsea have only won three of their last eight Premier League matches against Southampton at Stamford Bridge, and lost last season's fixture 3-1.
However, Chelsea have only lost two of the 16 meetings between the clubs since 2002 (W9, D5).
The Blues have lost two of their last four league games, twice as many as in the previous 22 matches.
Chelsea have gone 10 Premier League games without keeping a clean sheet for the first time since a run of 13 matches in December 1996.
Diego Costa's next Premier League goal will be his 50th in the competition but he could fail to score in six consecutive league appearances for the first time since January 2013.
Eden Hazard has equalled his best return of 14 Premier League goals in a season. He has only once scored more often in a campaign: 20 goals for Lille in 2011-12.
Southampton have won three of their last four Premier League away games, scoring 10 goals.
Claude Puel's side haven't beaten a team currently in the top six of the Premier League all season, drawing two and losing six.
Manolo Gabbiadini scored six goals in his first four appearances for the Saints but has failed to add to that tally in his last two games.
Cedric Soares could become the first Southampton player since Kevin Davies in 2001 to receive a yellow card in four consecutive Premier League matches.
Bet 365: Chelsea: 4/9 - Draw: 15/4 - Southampton: 15/2
Bet Victor: Chelsea: 9/20 - Draw: 18/5 - Southampton: 15/2
Follow the action with live tweets here (please note, we're not responsible for its content).