Date/time: 10/05/2017, 19:45 (UK), 14:45 ET, 11:45 PT (USA)
Venue: St. Mary's, Southampton, UK
TV: None (UK), NBCSN (USA) and check out LiveSoccerTV for alternatives.
Streaming: None (UK), NBCSN (USA)
Radio: BBC Radio Solent (UK)
Southampton earned a hard-fought point away at Liverpool on Sunday as they hone in on eighth place in the Premier League. That result at Anfield inspired Arsene Wenger's Arsenal, whose Champions League hopes dangling by a thread, as seen in their 2-0 win over Manchester United just hours later.
Saints boss Claude Puel says there aren't any fresh injury concerns, though the team could look different on Wednesday evening due to fatigue.
Puel also said the long-crocked pair of Charlie Austin and Matt Targett are both nearing a return to first team action.
Arsenal captain Laurent Koscielny is a doubt due to a calf injury, though Swiss midfielder Granit Xhaka is expected to be available despite picking up a similar injury against United on Sunday.
Puel, a former Wenger protege, will be hoping to earn some points off his former boss following an unfortunate loss (robbery via referee) at The Emirates earlier this season.
Stats Zone (via BBC Sport):
Southampton could win three consecutive home league games against Arsenal for the first time in 32 years.
Arsenal have not won a league fixture at St Mary's in five attempts since 2003 (L2, D3).
However, Southampton have won just six of 35 Premier League meetings overall, losing 19.
Saints are winless in four matches (D2, L2). A fifth match in a row without victory would be their worst run of the season.
They have only scored 11 goals in their last 12 Premier League home matches, failing to score in three of the last four.
However, 10th-placed Southampton could finish in the top half of the table in four straight top-flight campaigns for the first time.
A third goalless draw in a row would be a top-flight record for the club.
Manolo Gabbiadini registered four goals in his first three appearances but has failed to score in the last five, managing just one shot on target.
Arsenal have lost five of their last six away league games - as many defeats as they had suffered in the previous 27 - and have kept one clean sheet in 13 away fixtures.
They have taken three points from a possible 27 away to sides in the current top 11 of the Premier League.
If the Gunners fail to make the top four it will be for the first time in Arsene Wenger's 20 seasons at the helm.
Their tally of 63 points after 34 matches is the same as this stage of last season, when they finished second. They can reach no higher than third in this campaign.
Wenger's first league championship came in France with Monaco in 1988 - a team which featured Claude Puel.
Alex Oxlade-Chamberlain has seven assists in the league this campaign - as many as he created in the previous five seasons.
Bet 365: Southampton: 13/5 - Draw: 14/5 - Arsenal: 21/20
Bet Victor: Southampton: 27/10 - Draw: 14/5 - Arsenal: 21/20
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