Date/time: 17/05/2017, 19:45 (UK), 14:45 ET, 11:45 PT (USA)
Venue: St. Mary's, Southampton, UK
TV: Sky Sports (UK), NBCSN (USA) and check out LiveSoccerTV for alternatives.
Streaming: Sky Go (UK), NBCSN (USA)
Radio: BBC Radio Solent (UK)
Southampton ended their winless run with a well-earned victory over already-relegated Middlesbrough on Saturday. Wednesday night, Claude Puel will be hoping his Saints side can avenge their unlucky EFL Cup final defeat to an out of sorts Manchester United team led by Jose Mourinho.
Now could be as good a time as any to take on United for Southampton, given the Red Devils' hopes of a top four Premier League finish were extinguished by Tottenham Hotspur on Sunday. Now, Mourinho's focus will be trained on United's Europa League final against Ajax.
Puel made plenty of changes to his Saints side on Saturday and could well do the same on Wednesday evening. Charlie Austin, who has been out with an injured shoulder since December, could be in line to return after recovering five months later.
In terms of United news, Mourinho will definitely not be playing star midfielder Paul Pogba, who is on compassionate leave following the death of his father. Marouane Fellaini is expected to deputise in Pogba's absence after serving a ban.
Stats Zone (via BBC Sport):
Southampton have failed to beat Manchester United at home in eight league and cup games since a 1-0 win in August 2003.
United have lost just seven of 35 Premier League games against the Saints.
The Reds have come from behind to beat Southampton on eight occasions in the Premier League (including in this fixture last season) - the highest total for one team against another in the competition's history.
Four of Manchester United's five goals against Southampton in all competitions this season have been scored by Zlatan Ibrahimovic (now ruled out through injury).
Only relegated Sunderland have scored fewer home league goals than Southampton's 17 this season.
Premier League games at St Mary's have produced 37 goals this term - only Old Trafford (36 goals) has witnessed fewer goals.
Saints have won just once at home in their last seven games in all competitions (D2, L4).
They haven't scored a goal in their last three fixtures at St Mary's, since a 3-1 win over Crystal Palace on 5 April. They have never gone four top-flight home games without a goal.
Claude Puel's side have not won a league match against a team in the current top six this season (D3, L8).
United haven't lost three successive Premier League games in a row since December 2015, under Louis van Gaal.
They have claimed 17 league wins this term and need maximum points from their remaining two games to avoid recording their lowest tally of victories in a Premier League season. They won 19 matches in 2013-14 and 2015-16.
They have drawn 14 top-flight games this term, a league-high. The last time they ended a season with a higher total was in 1991-92 (15 draws in a 42-game campaign).
Jose Mourinho's side have won more points away from home this season in the Premier League (34 in 18 games) than they have at Old Trafford (31 in 18 matches).
Wayne Rooney's only previous goals at St Mary's came for Everton in a 3-3 draw on 21 February 2004.
Bet 365: Southampton: 17/10 - Draw: 9/4 - Manchester United: 15/8
Bet Victor: Southampton: 17/10 - Draw: 23/10 - Manchester United: 15/8
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