Date/time: 23/09/2017, 15:00 (UK), 10:00 ET, 07:00 PT (USA)
Venue: St. Mary’s Stadium, Southampton, UK
TV: None (UK), NBC Sports Gold (USA) and check out LiveSoccerTV for alternatives.
Streaming: None (UK), NBCSN (USA)
Radio: BBC Radio Solent (UK)
Southampton did well to bounce back with victory over Premier League strugglers Crystal Palace last week following a disappointing 2-0 defeat at home to Watford the game previous.
Just five games in, Saints find themselves in ninth place in the Premier League on eight points—joining another six teams on the same total so far including Tottenham Hotspur and Liverpool.
This week’s opponents, Jose Mourinho’s Manchester United, have had a great start to the season only dropping two points from a total of 15.
United are presently positioned second in the division on goal difference.
There are no fresh injury concerns for either side, though Marcos Rojo and Paul Pogba remain sidelined with injury for United.
Southampton defender Virgil van Dijk could make his first start for Saints since January.
Stats Zone (via BBC Sport):
Southampton's 24 Premier League defeats in this fixture is their worst record against any opponent.
Manchester United have won 16 of the last 22 meetings, losing just three.
Saints could equal their longest Premier League winless streak at home against a single opponent. They have gone seven games without victory against Middlesbrough (1998-2004) and Liverpool (1994-2000).
Southampton have failed to score in eight of their last 10 Premier League matches at St Mary's, and managed two home wins in 11.
However, they have kept three clean sheets in five games this season.
An 11th league defeat of the year against United would match their total number of losses in 2016 - with 15 matches still to play.
Southampton were winless last season in all 12 matches against sides who finished in the top six (D4, L8).
Former Valencia boss Mauricio Pellegrino failed in his four attempts to beat Jose Mourinho's Real Madrid (D2, L2).
A fifth victory in six matches would give United a club record-equalling 16 points at this stage of a Premier League campaign.
However, the Red Devils have triumphed only once in six away league fixtures (D3, L2).
They have scored nine goals in the 80th minute or later - more than the total goal tally of 17 Premier League rivals.
A league-high eight players have scored for United this season.
Henrikh Mkhitaryan has already been involved in six Premier League goals this season - one more than throughout the previous campaign.
Romelu Lukaku could become the first Premier League player to score at St Mary's for three clubs, having already done so for Everton and West Brom.
Bet 365: Southampton: 9/2 - Draw: 14/5 - Manchester United: 8/11
Bet Victor: Southampton: 22/5 - Draw: 14/5 - Manchester United: 8/11
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