Stuart Armstrong’s breakout game was spoilt by Fulham, as Southampton was defeated 3-2 at Craven Cottage.
Armstrong, who was coming off a strong performance with Scotland over the international break, struck either side of the break, including a sensational second goal.
But Aleksandar Mitrovic scored either side of Andre Schurrle’s late first-half goal to give new boss Claudio Ranieri a warm welcome to the job.
Southampton holds idle in 17th place, but the win Fulham draw level on eight points.
Fulham: Rico, Christie, Odoi, Mawson, Marchand, Chambers, Seri (Johansen 68), Cairney, Sessegnon, Schurrle (Karmara 74), Mitrovic (Ayite 86).
Unused subs: Bettinelli, Ream, Bryan, Kebano, Ayite.
Goals: Schurrle (43), Mitrovic (33, 63).
Bookings: Mawson (45+1).
Southampton: McCarthy, Targett, Hoedt, Yoshida, Cedric, Lemina, Hobjerg, Redmond, Armstrong (Obafemi 81), Gabbiadini, Austin (Elyounoussi 68).
Unused subs: Gunn, Vestergaard, Stephens, Ward-Prowse, Davis.
Bookings: Armstrong (18, 53).