Southampton has strung back-to-back Premier League wins together for the first time since April 2017 following a 3-1 triumph at Huddersfield.
Nathan Redmond and Danny Ings appeared to have done enough for a methodical first-half for Southampton, but Philip Billing slashed Huddersfield’s deficit in half after the restart.
Isaac Mbenza nearly equalised 120 seconds later, but Obafemi made an immediate impact off the bench and became Saints’ youngest Premier League goalscorer in the process.
Southampton — coming off an unexpected victory over Arsenal and the first under new manager Ralph Hasenhüttl — continues to climb away from danger moving into 16th in the table.
Redmond, who scored for the first time since May, raced onto a pass threaded through the heart of the defence by Pierre Emile Hojbjerg, before Ings made it 2-0 with his eight goal of the season coming from the penalty spot.
A reactionary save from Alex McCarthy on Zanka in the 55th minute maintained a two-goal gap, but three minutes later Billing thrashed an effort from distance past the wrong-footed keeper.
Mbenza could have brought Huddersfield level within a two-minute span, but McCarthy made a smart low save at the near post.
Obafemi could’ve restored Southampton’s two-goal lead, but failed to guide his shot into an empty net — the forward would be second-time lucky as he slotted in after Redmond outworked his defender.
Huddersfield: Lossl, Kongolo, Bacuna (Kachunga 65), Biling, Lowe, Mbenza (Quaner 81), Pritchard, Mounie, Zanka, Schindler, Hadergjonaj.
Unused subs: Hamer (GK), Diakhaby, Depoitre, Stankovic, Durm.
Goals: Billing (58).
Bookings: Lowe (11), Zanka (63).
Southampton: McCarthy, Targett, Yoshida, Vestergaard, Bednarek, Valery (Stephens 79), Hojbjerg, Romeu, Armstrong (Lemina 68), Redmond, Ings (Obafemi 65).
Unused subs: Gunn (GK), Ramsay, Long, Austin.
Goals: Redmond (15), Ings (42).
Bookings: Valery (52), Stephens (84), Hojbjerg (86).